Drug-induced Photosensitivity: Photoallergic, Phototoxic and Adverse Drug Reactions
Year: 2024; Volume: 4; Issue: 4; Page No: 23 – 28
Article Type: Short Communication
Authors: Bayan Omar Sharif 1*
, Naza Mohammed Ali Mahmood2, Sakar Bikhtiyar Saber3, Danyar Akbar Muhamad4, Shanar Jamal Rahim5, Frishta Ahmed Salih6
https://doi.org/10.55349/ijmsnr.2024442328
Affiliations:
1Specialist Nurse, Sulaimani Directorate of Health, Health Development and Training Center, Kurdistan Region, Iraq.
2Assisstant Professor, University of Sulaimaniyah, College of Pharmacy, Pharmacology & Toxicology Department, Kurdistan Region, Iraq.
3Pharmacist, Shorsh General Hospital, Kurdistan Region, Iraq.
4 Nurse, Baxshin Hospital, Kurdistan Region, Iraq.
5Biologist, College of Science – Biology department, University of Sulaimani, Kurdistan Region, Iraq.
6 Pharmacist, Zad medical center, Iraq.
| How to cite this article: Sharif BO, Mahmood NMA, Saber SB, Muhamad DA, Rahim SJ, Salih FA. Drug-induced Photosensitivity: Photoallergic, Phototoxic and Adverse Drug Reactions. Int J Med Sci and Nurs Res 2024;4(4):23–28. DOI: 10.55349/ijmsnr.2024442328 |
Article Summary: Submitted: 25-October-2024 Revised: 28-November-2024 Accepted: 25-December-2024 Published: 30-December-2024
Abstract
Background: Drug-induced photosensitivity refers to skin reactions caused by exposure to ultraviolet light following the use of certain medications, which can be administered topically or orally. When ultraviolet radiation interacts with a chemical present in adequate concentrations within the skin, it may trigger various reactions, particularly in susceptible individuals. The most common responses are photoallergic and phototoxic reactions.
Methods: In this paper, we discussed about drug-induced photosensitivity: Photoallergic, phototoxic and adverse drug reactions, and some of those medication that leads to these conditions.
Results: Photosensitive drug eruptions are cutaneous adverse events due to exposure to a medication and either ultraviolet or visible radiation.
Conclusion: Photosensitive drugs (PSDs) represent an important research area and more investigations would be helpful to better predict drug photosensitizing potential, prevent and manage cutaneous adverse events and find the most appropriate alternative therapeutic strategy. As well as, various medications, particularly antibiotics and analgesics, can induce both photoallergic and phototoxic reactions, there are significant differences between the two, including their onset timing, requirement for prior exposure, underlying mechanisms, clinical presentation, and histopathological features.
Keywords: drug-induced photosensitivity, photoallergic, phototoxic, adverse drug reactions, medications
Source of funding: None
Conflict of Interest: None
Corresponding Author:
Dr. Bayan Omar Sharif,
Sulaimani Directorate of Health,
Health Development and Training Center,
Kurdistan Region,
Iraq.
Email ID: omerbayn82@gmail.com
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